Carmustine－懷念睿寶貝 Memory for Ray baby

Carmustine
系統(IUPAC)名字
1,3bis (2chloroethyl) - 1亞硝基尿素
標識符
CAS數字	154-93-8
ATC代碼	L01AD01
PubChem	2578
DrugBank	APRD00006
化工數據
慣例	C₅H₉分類₂N₃O₂
Mol. 大量	214.049 g/mol
約物動力學的數據
生物相容性	5到28% (口頭)
蛋白質捆綁	80%
新陳代謝	肝 (CYP1A2-斡旋)
半生活	15

資料來源:http://en.wikipedia.org/wiki/Carmustine

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Systematic (IUPAC) name

Identifiers

CAS number

ATC code

PubChem

DrugBank

ChemSpider

UNII

KEGG

ChEMBL

Chemical data

Formula

Mol. mass

SMILES

Pharmacokinetic data

Bioavailability

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Metabolism

Half-life

Therapeutic considerations

Pregnancy cat.

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Carmustine
N,N'-bis(2-chloroethyl)-N-nitroso-urea
154-93-8
L01AD01
CID 2578
APRD00006
2480^Y
U68WG3173Y^Y
D00254^Y
CHEMBL513^Y
C₅H₉Cl₂N₃O₂
214.049 g/mol
eMolecules & PubChem
InChI [show] InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)^Y Key: DLGOEMSEDOSKAD-UHFFFAOYSA-N^Y
5 to 28% (oral)
80%
Hepatic (CYP1A2-mediated)
15 to 30 minutes
D(US)
℞ Prescription only
Intravenous, wafer for implant

Carmustine or BCNU (= "bis-chloronitrosourea") is a mustard gas-related α-chloro-nitrosourea compound used as an alkylating agent in chemotherapy.

Carmustine for injection is marketed under the name BiCNU by Bristol-Myers Squibb.

Uses

It is used in the treatment of several types of brain cancer (including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma and lymphoma (Hodgkin's and non-Hodgkin).

Side effects

Male infertility.

Bone marrow may take 6 weeks to recover function following treatment with carmustine. Weekly monitoring of platelet and white blood cell counts are recommended as a basis for patient-specific adjustments to dosage regimens. Bone marrow and pulmonary toxicities are a function of lifetime cumulative dose.